Ammonia → HCID 57958821, compound

HRID 1774117Notes

Reaction equation

HRID 1774117 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH3:19]>CO>[NH2:19][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 57958802HCID 57958802, compound

Product 1

HCID 57958821HCID 57958821, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was synthesized from 4-chloro-6-(4-fluorophenyl)-quinazoline and a 7 N ammonia solution in methanol in 84%, using the procedure described for example 37. The product was characterized by its mass spectrum as follows: MS (m/z): 240 ([M+H]+, 100).

Sources & evidence

ORD record
ord-ddabf87eefd24a4185d4f311985cc9e3
Source dataset
uspto-grants-2016_02
Patent number
US09259426B2

Reaction notes

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