4-Fluorophenylboronic acid → HCID 69014769, compound

HRID 1774129Notes

Reaction equation

HRID 1774129 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=1)[N:6]=[C:5]2[NH:24][CH2:25][C:26]([F:29])([F:28])[F:27].[F:30][C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1>>[F:30][C:31]1[CH:36]=[CH:35][C:34]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]=[C:7]([NH:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:18][CH:19]=2)[N:6]=[C:5]3[NH:24][CH2:25][C:26]([F:27])([F:28])[F:29])=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 69012110HCID 69012110, compound

Product 1

HCID 69014769HCID 69014769, compound

Procedure

The title compound was synthesized by analogy to Example 51 using 4-{[6-bromo-4-(2,2,2-trifluoro-ethylamino)-quinazolin-2-ylamino]-methyl}-benzenesulfonamide and 4-fluorobenzene boronic acid. The resulting product was characterized as follows: MS (m/z): 506 ([M+H]+, 100); HPLC Rt=2.85 minutes (Method A).

Sources & evidence

ORD record
ord-fab82287103a49c29e554d12be88a790
Source dataset
uspto-grants-2016_02
Patent number
US09259426B2

Reaction notes

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