HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (E)-ethyl 3-(4-chloro-3-fluorophenyl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 4-Chloro-3-fluorocinnamic acid | HCID 5708403 | — |
| Product | (E)-ethyl 3-(4-chloro-3-fluorophenyl)acrylate | HCID 86696656 | 99.65% |
Reaction Steps
(E)-3-(4-Chloro-3-fluorophenyl)acrylic acid (17.3 g, 86.24 mmol) was suspended in ethanol (200 mL), and chlorotrimethylsilane (24.00 mL, 189.7 mmol) was added. The mixture was then agitated for 20 hours and evaporated, to give (E)-ethyl 3-(4-chloro-3-fluorophenyl)acrylate (19.65 g, 85.94 mmol, 99.65% yield) as an oil, which solidified later.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09259470B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-00df0bfd79f54c35a47f69ed49d6f61a |
| Source note | uspto-grants-2016_02 |