4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

Participants

Role	Name	HCID	Charge
Reactant	4-Chloropyridine	HCID 12288	—
Reactant	2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine	HCID 59699242	—
Solvent	Dimethylformamide	HCID 6228	—
Product	[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine	HCID 59699105	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07737285B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-f4c5cc306db44e75b408cc77c88ae295
Source note	uspto-grants-2010_06