Bis(2,2,2-trifluoroethyl) Carbonate → HCID 19809734, compound

HRID 1774250Notes

Reaction equation

HRID 1774250 reaction equation
C(=O)(OCC(F)(F)F)OCC(F)(F)F.FC(F)(F)C[NH:18][C:19](=[O:38])[O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][O:29][C:30](=[O:37])[NH:31]CC(F)(F)F)[CH:23]=1>>[C:30](=[O:37])([O:29][CH2:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:22]([CH2:21][O:20][C:19](=[O:38])[NH2:18])[CH:23]=1)[NH2:31]

Participants

3

Reactant 2

HCID 11447463Bis(2,2,2-trifluoroethyl) CarbonateHCID 86676002HCID 86676002, compound

Product 1

HCID 19809734HCID 19809734, compoundYield 93.5%

Procedure

The reaction was carried out in the same manner as Example 3 except for using 37.1 g (0.1642 mol) of bis(2,2,2-trifluoroethyl) carbonate (to be referred to as “BTrFC” hereinafter) synthesized in the above Synthesis Example 2 in place of BTFC, and it was confirmed that m-xylylene bis(2,2,2-trifluoroethyl carbamate) (to be referred to as XDC-2 hereinafter) was generated as the main product (XDA base yield 93.5%). Structural assignment of the product XDC-2 was carried out by 19F-NMR and GC-Mass analyses as well as 1H-NMR. Analytical Results of mass fragments of XDC-2, 1H-NMR and 19F-NMR were shown in the following.

Workup

  1. customsynthesized in the above Synthesis Example 2 in place of BTFC, and it
  2. customAnalytical Results of mass fragments of XDC-2, 1H-NMR and 19F-NMR

Sources & evidence

ORD record
ord-d4c614eeb0be473b8fb61f4619bb3736
Source dataset
uspto-grants-2016_02
Patent number
US09260383B2

Reaction notes

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