Bis(2,2,2-trifluoroethyl) Carbonate → HCID 86676005, compound

HRID 1774252Notes

Reaction equation

HRID 1774252 reaction equation
C(=O)(OCC(F)(F)F)OCC(F)(F)F.FC(F)(F)C[NH:18][C:19](=[O:38])[O:20][CH2:21][CH:22]1[CH:27]=[CH:26][CH2:25][CH:24]([CH2:28][O:29][C:30](=[O:37])[NH:31]CC(F)(F)F)[CH2:23]1>>[C:30](=[O:37])([O:29][CH2:28][CH:24]1[CH:25]=[CH:26][CH2:27][CH:22]([CH2:21][O:20][C:19](=[O:38])[NH2:18])[CH2:23]1)[NH2:31]

Participants

3

Reactant 2

HCID 11447463Bis(2,2,2-trifluoroethyl) CarbonateHCID 86676006HCID 86676006, compound

Product 1

HCID 86676005HCID 86676005, compoundYield 93.2%

Procedure

The reaction was carried out in the same manner as Example 7 except for using 37.1 g (0.1642 mol) of bis(2,2,2-trifluoroethyl) carbonate (to be referred to as “BTrFC” hereinafter) synthesized in the above Synthesis Example 2 in place of BTFC, and it was confirmed that tetrahydro-m-xylylene bis(2,2,2-trifluoroethyl carbamate) (to be referred to as H-XDC-2 hereinafter) was generated as the main product (H-XDA base yield 93.2%). Structural assignment of the product H-XDC-2 was carried out by 19F-NMR and GC-Mass analyses as well as 1H-NMR. Analytical Results of mass fragments of H-XDC-2, 1H-NMR and 19F-NMR were shown in the following.

Workup

  1. customsynthesized in the above Synthesis Example 2 in place of BTFC, and it
  2. customAnalytical Results of mass fragments of H-XDC-2, 1H-NMR and 19F-NMR

Sources & evidence

ORD record
ord-538ec03a8fce47bca5573140f1eece0b
Source dataset
uspto-grants-2016_02
Patent number
US09260383B2

Reaction notes

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