Isobutyraldehyde → HCID 70559858, compound

Participants

Reaction Steps

Isobutyraldehyde (370 μl, 4 mmol), isopropyl methyl ketone (250 μl, 4 mmol), malononitrile (264 mg, 4 mmol) e ammonium acetate (462 mg, 6 mmol) were placed in a microwave tube and irradiated with microwaves (Solvent: none; Power: 250 W; Ramp time: 1 min; Heating time: 10 min; Temperature: 100° C.; Pressure: 250 psi; Stirring: on; Cooling: on). At the end of the microwave irradiation cycle, the solvent was removed under reduced pressure. The crude product was purified by flash chromatography on silica gel (methylene chloride/methanol=90/10) to obtain 2-amino-4,6-diisopropylnicotinonitrile in 50% yield.

Provenance & Evidence