1386927-90-7 → HCID 71061887, compound

HRID 1774318Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)=[O:8].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N:31]2[CH2:36][CH2:35][N:34]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]3[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=3)=[O:8])[CH2:33][CH2:32]2)=[CH:23][CH:24]=1

Participants

Reactant 2

HCID 220016181386927-90-7

HCID 86713097HCID 86713097, compound

Product 1

HCID 71061887HCID 71061887, compound

Procedure

The title compound was prepared starting from 6-bromo-N-(4-pyridylmethyl)hexa namide and 1-[2-(4-methoxyphenyl)phenyl]piperazine following the procedure outlined for Example 21. 1H NMR (CDCl3): δ 1.34-1.43 (m, 2H), 1.53-1.63 (m, 2H), 1.67-1.77 (m, 2H), 2.28 (t, 2H, J=7.4 Hz), 2.42 (app. t, 2H), 2.66 (br s, 4H), 3.10 (br s, 4H),3.81 (s, 3H), 4.45 (d, 2H, J=6.1 Hz), 6.10 (br t, 1H, D2O exchanged), 6.94 (d, 2H, J=8.8 Hz), 7.00 (d, 1H, J=8.0 Hz), 7.09-7.16 (m, 3H), 7.22-7.30 (m, 2H), 7.46 (d, 2H, J=8.8 Hz), 8.55 (dd, 2H, J=1.4, 4.4 Hz). GC-MS m/z 473 (M+1, 1), 472 (M+, 5), 379 (15), 282 (82), 226 (100), 210 (43).

Sources & evidence

ORD record: ord-53c3ac5689ae4150a953417153a73814
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260400B2

Reaction notes

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