HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1774385Generated: October 30, 2026
Ethyl acetate hexane → 2-Isopropyl-3-methylmaleic anhydride
https://huagongshe.com/reaction/1774385
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 2-Hydroxy-2-isopropyl-3-methylsuccinic acid | HCID 86102327 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | 2-Isopropyl-3-methylmaleic anhydride | HCID 53784241 | 40% |
Reaction Steps
The 2-hydroxy-2-isopropyl-3-methylsuccinic acid thus obtained was dissolved in acetic anhydride (30 mL), and stirred at 110° C. for 15 h. The acetic anhydride was evaporated under reduced pressure, and the residue thus obtained was subjected to silica gel column chromatography (hexane-ethyl acetate 19:1) to give 203 mg of the title compound as oil (yield: 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09260375B2 |
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| Source dataset | uspto-grants-2016_02 |
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| ORD ID | ord-9179c2db645f4b619453b65d7c7b0a01 |
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| Source note | uspto-grants-2016_02 |
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