Lithium Hydroxide → HCID 71078000, compound

Participants

Reaction Conditions

Reaction Steps

5-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-nicotinic acid methyl ester (0.050 g, 0.15 mmol) was dissolved in MeOH:THF (1:1, 4 mL) and LiOH (1 M aq., 1 mL) was added. The reaction was heated to 50° C. for 3.5 hours then cooled. The reaction was acidified with HCL (1 M aq., 1 mL), diluted with EtOAc, dried over MgSO4, then filtered and concentrated to supply the title compound. Mass spectrometric data: [M+H]+=319.

Provenance & Evidence