Lithium Hydroxide → HCID 71078046, compound

Participants

Reaction Steps

5-[6-Chloro-2-methyl-1-(1-methyl-1H-pyrazol-4-yl)-1H-indol-3-ylsulfanyl]-nicotinic acid methyl ester (from the previous step) was dissolved in THF:MeOH (1:1, 4 mL) and LiOH (1 M aq., 2 mL) was added. After 15 minutes the reaction mixture was concentrated to dryness then purified via preparatory HPLC (10-100% ACN in H2O, 15 minute run, r.t.=8.21 minutes) to provide the desired product. Mass spectrometric data: [M−H]=397.

Provenance & Evidence