Potassium Phosphate, Tribasic → HCID 71078090, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	N,N-Dimethylethylenediamine	HCID 66053	—
Reactant	4-Bromo-1-ethyl-1H-pyrazole	HCID 12565201	—
Reactant	HCID 71078056	HCID 71078056	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Solvent	Toluene	HCID 1140	—
Product	HCID 71078090	HCID 71078090	—

Reaction Conditions

Temperature	120 °C

Reaction Steps

6-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-pyridine-2-carboxylic acid ethyl ester (0.0563 g, 0.16 mmol), 4-bromo-1-ethyl-1H-pyrazole (0.042 g, 0.24 mmol), tripotassium phosphate (0.067 g, 0.32 mmol), copper(I) iodide (0.006 g, 0.032 mmol) and N,N-dimethylethylenediamine (0.014 mL, 0.13 mmol) were combined in toluene (1 mL) in a sealed vial. The mixture was heated to 120° C. overnight. The crude reaction mixture was used directly in the next step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09260416B2
Source dataset	uspto-grants-2016_02
ORD ID	ord-b95bdd2d2a5048f687778f0557c22516
Source note	uspto-grants-2016_02