4-Bromo-1-isopropyl-1H-pyrazole → HCID 71078227, compound

HRID 1774502Notes

Reaction equation

HRID 1774502 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][C:13]2[C:21]3[C:16](=[C:17]([F:23])[C:18]([Cl:22])=[CH:19][CH:20]=3)[NH:15][C:14]=2[CH3:24])[N:7]=1)=[O:5])[CH3:2].Br[C:26]1[CH:27]=[N:28][N:29]([CH:31]([CH3:33])[CH3:32])[CH:30]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][C:13]2[C:21]3[C:16](=[C:17]([F:23])[C:18]([Cl:22])=[CH:19][CH:20]=3)[N:15]([C:26]3[CH:27]=[N:28][N:29]([CH:31]([CH3:33])[CH3:32])[CH:30]=3)[C:14]=2[CH3:24])[N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 223292004-Bromo-1-isopropyl-1H-pyrazoleHCID 71078170HCID 71078170, compound

Product 1

HCID 71078227HCID 71078227, compound

Procedure

Prepared according to the procedure described in Example 9, Step 4, using the following starting materials: 6-(6-chloro-7-fluoro-2-methyl-1H-indol-3-ylsulfanyl)-pyridine-2-carboxylic acid ethyl ester and 4-bromo-1-isopropyl-1H-pyrazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2881dbed577b429083fcf586531f65fc
Source dataset
uspto-grants-2016_02
Patent number
US09260416B2

Reaction notes

Loading…