2-(Ethoxymethylene)propanedinitrile → HCID 89648919, compound

Participants

Reaction Conditions

Reaction Steps

146 mg of sodium methanolate (2.70 mmol, 1.0 eq) were diluted in 20 ml of methanole at room temperature under a nitrogen atmosphere. Then 1.0 g of 5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazole-3-carboximidamide hydrochloride 1:1 1-3-6 (2.70 mmol, 1.0 eq) and 329 mg of (ethoxymethylene)malononitrile (2.70 mmol, 1.0 eq) were added and the mixture was stirred at 65° C. bath temperature for 18 hours. After cooling to rt the reaction mixture was concentrated in vacuo and purified via HPLC (ACN/H2O/0.2% NH3) to give 284 mg (0.65 mmol, 24%) of analytically pure target compound.

Provenance & Evidence