HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Picolinohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | Dabco | HCID 9237 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Methyl 3-mercaptobenzoate | HCID 4362804 | — |
| Product | Picolinohydrazide | HCID 255881 | — |
Reaction Steps
Compound 42 is prepared from methyl 3-mercaptobenzoate (41) and compound 42 under basic condition (e.g. 2-6-lutidine or DABCO). The ester functional group of compound 43 is then converted to hydrazide first (hydrazine reaction) and then Boc protecting group is deprotected under acidic condition (e.g. TFA) to afford compound 44.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260417B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-00bf975c526f45cb96d14b7ac143e757 |
| Source note | uspto-grants-2016_02 |