HCID 118389543, compound → HCID 73507792, compound

HRID 1774561Notes

Reaction equation

[C:1]([O:5][CH:6]([C:11]1[N:15]([CH3:16])[N:14]=[C:13]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)[C:12]=1[C:22]1[CH:23]=[CH:24][C:25]2[O:30][CH2:29][CH2:28][CH2:27][C:26]=2[CH:31]=1)[C:7]([O:9]C)=[O:8])([CH3:4])([CH3:3])[CH3:2].CC(OC(C)(C)C)(C1N(C)N=C(C2SC=CC=2)C=1C1C=CC2OCCCC=2C=1)C(O)=O>>[C:1]([O:5][CH:6]([C:11]1[N:15]([CH3:16])[N:14]=[C:13]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)[C:12]=1[C:22]1[CH:23]=[CH:24][C:25]2[O:30][CH2:29][CH2:28][CH2:27][C:26]=2[CH:31]=1)[C:7]([OH:9])=[O:8])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 118389543HCID 118389543, compound

HCID 118389559HCID 118389559, compound

Product 1

HCID 73507792HCID 73507792, compound

Procedure

Using the procedure described in example 1, step 7, methyl 2-(tert-butoxy)-2-[4-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl]acetate (3f) (110 mg, 0.25 mmol) is converted into methyl 2-(tert-butoxy)-2-[4-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl]acetic acid (example 3) (97 mg, 0.23 mmol, 91%).

Sources & evidence

ORD record: ord-a8bd3416ad914324b66e3ecf2ed3ff5e
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260395B2

Reaction notes

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