Hydrochloric Acid → HCID 90092924, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-[4-bromo-5-(dimethoxymethyl)-1-methyl-1H-pyrazol-3-yl]-1,3-thiazole (8d) (586 mg, 1.84 mmol) in tetrahydrofuran (15 mL) was treated with 1N hydrochloric acid (2.26 mL) and the mixture was stirred at 50° C. for 5 hours. The reaction was cooled to room temperature and then neutralized with 1N sodium hydroxide (2.26 mL). The resulting mixture was extracted with ethyl acetate (2×15 mL) and the organic layer was dried over sodium sulfate and concentrated in vacuo to provide 4-bromo-1-methyl-3-(1,3-thiazol-2-yl)-1H-pyrazole-5-carbaldehyde (8e) (480 mg, 1.76 mmol, 96%) which was used without further purification.

Provenance & Evidence