HCID 73603516, compound → HCID 73603519, compound

Participants

Reaction Steps

A mixture of 2-(tert-butoxy)-2-[3-(cyclopent-1-en-1-yl)-4-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-methyl-1H-pyrazol-5-yl]acetic acid (example 12) (19.7 mg, 0.047 mmol) and palladium on carbon (7 mg) in methanol (2.4 mL) was stirred under hydrogen atmosphere overnight. The mixture was filtered over Millipore and the filtrate was concentrated in vacuo to provide 2-(tert-butoxy)-2-[3-cyclopentyl-4-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-methyl-1H-pyrazol-5-yl]acetic acid (example 19) (19.5 mg, 0.047 mmol, 98%) as a white solid.

Provenance & Evidence