Chlorosuccinimide → HCID 90092618, compound

Participants

Reaction Steps

A solution of 4-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-methyl-3-(thiophen-2-yl)-1H-pyrazole-5-carbaldehyde (3d) (166 mg, 0.51 mmol) and N-chlorosuccinimide (67 mg, 0.50 mmol) in acetonitrile (18 mL) was heated overnight at 60° C. The reaction mixture was concentrated in vacuo. Water (10 mL) was added and the aqueous layer was extracted with ethyl acetate (2×12 mL). The organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified by preparative TLC (cyclohexane/ethyl acetate 80/20), to provide 3-(5-chlorothiophen-2-yl)-4-(3,4-dihydro-2H-1-benzopyran-6-yl)-1-methyl-1H-pyrazole-5-carbaldehyde (36a) (183 mg, 0.51 mmol, 99%).

Provenance & Evidence