HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylic Acid → N-(2-(6-aminopyridin-2-ylamino)ethyl)acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | N2-(2-aminoethyl)pyridine-2,6-diamine hydrochloride | HCID 118117145 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-(6-aminopyridin-2-ylamino)ethyl)acrylamide | HCID 118116459 | 52% |
Reaction Steps
A mixture of 105c (1.88 g, 10 mmol), acrylic acid (720 mg, 10 mmol), HATU (3.80 g, 10 mmol) and DIPEA (6.97 mL, 40 mmol) in DCM (50 mL) was stirred at rt for 16 h. The reaction mixture was concentrated and the residue was purified by silica gel chromatography (EA/MeOH=4/1) to give N-(2-(6-aminopyridin-2-ylamino)ethyl)acrylamide 105d (1.07 g, 52%) as pale-yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260415B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-07bed91add7143f2a42c4d395ecea7d5 |
| Source note | uspto-grants-2016_02 |