HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-3-(6-(2-aminopropoxyl)pyridin-2-ylamino)-5-bromo-1-methylpyridin-2(1H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-tert-butyl 1-(6-(5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-2-yloxy)propan-2-ylcarbamate | HCID 118117363 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-3-(6-(2-aminopropoxyl)pyridin-2-ylamino)-5-bromo-1-methylpyridin-2(1H)-one hydrochloride | HCID 118117014 | 85.1% |
Reaction Steps
A mixture of 107b (550 mg, 1.21 mmol) in DCM (10 mL) was treated with HCl (4 M in dioxone, 3 mL, 12 mmol). The reaction mixture was stirred at rt for 2 h and quenched with sat. Na2CO3, extracted with DCM. The combined extracts were dried over Na2SO4, filtered and concentrated to give 107c (400 mg, 1.03 mmol) as brown solid. MS-ESI: [M+H]+ 352.9
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260415B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-d1ca42179832462994ec2f6d11a629da |
| Source note | uspto-grants-2016_02 |