HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylic Acid → HCID 118116622, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 118116348 | HCID 118116348 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118116622 | HCID 118116622 | 83.2% |
Reaction Steps
A mixture of 110c (1.2 g, 4.5 mmol), acrylic acid (0.37 mL, 5.4 mmol), HATU (2.05 g, 5.4 mmol) and DIPEA (4.6 mL, 10.8 mmol) in DCM (30 mL) was stirred at rt overnight. The mixture was washed with water. The organic layer was separated, dried over Na2SO4, filtered and concentrated to give tert-butyl 6-((2-acrylamidoethyl)(methyl)amino)pyridin-2-ylcarbamate 110d (1.2 g, 75%) as a brown oil. The material was used for the next step directly. ESI-LCMS: m/z=321.3
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260415B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-cbd264cc061b40ddb754515b38e1c801 |
| Source note | uspto-grants-2016_02 |