HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-bromo-1-methyl-3-(6-(2-(methylamino)ethoxy)pyridin-2-ylamino)pyridin-2(1H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 2-(6-(5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)pyridin-2-yloxy)ethyl(methyl)carbamate | HCID 118116879 | — |
| Product | 5-bromo-1-methyl-3-(6-(2-(methylamino)ethoxy)pyridin-2-ylamino)pyridin-2(1H)-one hydrochloride | HCID 118116483 | 85.1% |
Reaction Steps
A mixture of 112c (900 mg, 1.99 mmol) in HCl (5 mL, 4 M in 1,4-dioxane, 20 mmol) was stirred at rt for 2 h. The reaction mixture was concentrated to give 5-bromo-1-methyl-3-(6-(2-(methylamino)ethoxy)pyridin-2-ylamino)pyridin-2(1H)-one hydrochloride 112d (660 mg, 85%) as yellow solid. This material was used for next step directly. ESI-LCMS: m/z=354.9 (free base)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260415B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-3c2b9193eb804b8eacb1498edc8f0e12 |
| Source note | uspto-grants-2016_02 |