Hydrochloric Acid → HCID 118116442, compound

Participants

Reaction Steps

A mixture of 114a and 114b (2.3 g, 4.69 mmol) in HCl (10 mL, 4 M in 1,4-dioxane, 40 mmol) was stirred at rt for 7 h. The reaction mixture was concentrated to give (S)-tert-butyl 6-(3-aminopiperidin-1-yl)pyridin-2-ylcarbamate hydrochloride 114c (1.39 g, 90%) as yellow solid which was used for the next step directly.

Provenance & Evidence