Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malic Acid | HCID 525 | — |
| Reactant | Brexpiprazole | HCID 11978813 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 71295458 | HCID 71295458 | 101.8% |
Reaction Steps
A suspension of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)-butoxy]-1H-quinolin-2-one (15 g) in dichloromethane (100 ml) and methanol (100 ml) was warmed to 60° C., dissolved, and DL-malic acid (5.11 g) dissolved in water (10 ml) was added at room temperature. The precipitated crystals were collected by filtration, and dried to give 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)-butoxy]-1H-quinolin-2-one DL-malate (20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09260420B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-4680b25d25d54b418733d37f65f80850 |
|---|
| Source note | uspto-grants-2016_02 |
|---|
