Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Tartaric acid | HCID 444305 | — |
| Reactant | Brexpiprazole | HCID 11978813 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131734723 | HCID 131734723 | 95.6% |
Reaction Steps
A suspension of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)-butoxy]-1H-quinolin-2-one (15 g) in dichloromethane (100 ml) and methanol (100 ml) was heated to 60° C., dissolved, and L(+)-tartaric acid (5.72 g) dissolved in water (10 ml) was added at room temperature. The precipitated crystals were collected by filtration, and dried to give 7-[4-(4 benzo[b]thiophen-4-yl-piperazin-1-yl)-butoxy]-1H-quinolin-2-one L(+)-tartrate (19.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09260420B2 |
|---|
| Source dataset | uspto-grants-2016_02 |
|---|
| ORD ID | ord-5d5606508f0146a985fe3167534af726 |
|---|
| Source note | uspto-grants-2016_02 |
|---|
