反应详情

4-chloro-1H-pyrazolo[3,4-b]pyridine (6) 1 g (6.53 mmoles) in acetic acid (100 mL) cooled to 0° C. was added N-bromosuccinimide 2.31 g (13.06 mmol and the resulting RM was stirred for 4 hr at rt. After completion of the SM, the RM was quenched with ice water and extracted with dichlromethane (2×10 mL). The combined organic layer was dried over sodium sulphate, and the solvent evaporated to yield compound 7 (Yield: 0.9 g, 60%). 1H NMR (400 MHz, CDCl3): δ 13.19 (br s, 1H), 8.21 (s, 1H), 7.39 (m, 1H).

1. customAfter completion of the SM, the RM was quenched with ice water
2. extractionextracted with dichlromethane (2×10 mL)
3. dry with materialThe combined organic layer was dried over sodium sulphate
4. customthe solvent evaporated