HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dibromopyridine → HCID 178455459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dibromopyridine | HCID 69369 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | HCID 131734724 | HCID 131734724 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 178455459 | HCID 178455459 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-3 [B], (R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidine was reacted with 3,5-dibromopyridine in the presence of Pd2(dba)3, rac-BINAP and sodium tert-butoxide to give the title compound as a yellow oil. MS: 371.0, 372.9 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5a98852b7aae4fdf9e1c6f2033f87b0b |
| Source note | uspto-grants-2016_02 |