HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one → HCID 178481474, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one | HCID 72208233 | — |
| Reactant | HCID 178455459 | HCID 178455459 | — |
| Product | HCID 178481474 | HCID 178481474 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-3 [C], 1-methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one (intermediate A-1) has been coupled to 3-bromo-5-[(R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-pyridine to give the title compound as a white solid. MS: 452.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-cb10ef57c35740b0a5e22247b9794f69 |
| Source note | uspto-grants-2016_02 |