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HRID1774731

反应详情

EQUATION

反应方程式

HRID 1774731 的结构方程式

REACTANTS

反应物

4
结构：Brc1cncc(Br)c1
HCID69369

3,5-Dibromopyridine

C5H3Br2N

结构：c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1
HCID634876

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl

C44H32P2

结构：COC[C@@H]1CCCN1
HCID671217

(+)-(S)-2-(Methoxymethyl)pyrrolidine

C6H13NO

结构：CC(C)(C)[O-].[Na+]
HCID23676156

Sodium t-butoxide

C4H9NaO

PRODUCTS

生成物

1
结构：COC[C@@H]1CCCN1c1cncc(Br)c1
HCID86679115

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.[Pd].[Pd]
催化剂HCID9811564

Bis(dibenzylideneacetone)palladium

C51H42O3Pd2

PROCEDURE

实验过程

In analogy to the procedure described for the preparation of intermediate A-3 [B], (S)-2-methoxymethyl-pyrrolidine was reacted with 3,5-dibromopyridine in the presence of Pd2(dba)3, rac-BINAP and sodium tert-butoxide to give the title compound as a yellow oil. MS: 271.1, 273.1 (M+H+).