2-Pyrrolidone → 1-(5-Bromo-3-pyridinyl)-2-pyrrolidinone

HRID 1774735Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[Br:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12](Br)[CH:13]=1>>[Br:7][C:8]1[CH:13]=[C:12]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:11]=[N:10][CH:9]=1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 693693,5-Dibromopyridine

Product 1

HCID 686194601-(5-Bromo-3-pyridinyl)-2-pyrrolidinone

Procedure

In analogy to the procedure described for the preparation of intermediate A-9, pyrrolidin-2-one has been coupled to 3,5-dibromopyridine to yield the title compound as a light yellow solid. MS: 241.0, 243.0 (M+H+).

Sources & evidence

ORD record: ord-9260fd31dfb6419188542a8f5cac1b9b
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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