HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 178455462, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-5-(chloromethyl)pyridine | HCID 11701259 | — |
| Reactant | HCID 131734725 | HCID 131734725 | — |
| Product | HCID 178455462 | HCID 178455462 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediates A-12 [B], (S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidine (intermediate A-3 [A]) was reacted with 3-bromo-5-chloromethyl-pyridine (intermediate A-12 [A]) in presence of NaH to give the title compound as a yellow solid. MS: 385.2, 387.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5502f46194734d0ca4dbfeb332535e6a |
| Source note | uspto-grants-2016_02 |