HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dibromopyridine → HCID 86679134, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dibromopyridine | HCID 69369 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 2-Boc-2,6-diazaspiro(3.3)heptane | HCID 40151981 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 86679134 | HCID 86679134 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-3 [B], 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester was reacted with 3,5-dibromopyridine in the presence of Pd2(dba)3, rac-BINAP and sodium tert-butoxide to give the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-bd2e8d6a798a49449e67ce06805cba19 |
| Source note | uspto-grants-2016_02 |