HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 3-Bromo-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1,3-Propanesultam | HCID 642157 | — |
| Reactant | 3-Bromo-5-(chloromethyl)pyridine | HCID 11701259 | — |
| Product | 3-Bromo-5-(1,1-dioxo-isothiazolidin-2-ylmethyl)-pyridine | HCID 59578395 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-12 [B], isothiazolidine 1,1-dioxide was reacted with 3-bromo-5-chloromethyl-pyridine (intermediate A-12 [A]) in the presence of NaH to give the title compound as a light yellow oil. MS: 292.8 and 290.9 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-05f2883d30dd4c49a374010e31832bce |
| Source note | uspto-grants-2016_02 |