Potassium Carbonate → HCID 86679143, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(2-chloro-ethyl)-isothiazolidine-1,1-dioxide (0.046 g, 0.253 mmol) and 5-bromopyridin-3-ol (0.04 g, 0.230 mmol) in DMF (1 mL) was added K2CO3 (0.064 g, 0.46 mmol), followed by KI (0.008 g, 0.046 mmol) and the reaction mixture was heated to 60° C. and stirred over night. The mixture was diluted with EtOAc, poured into a sat. NaHCO3 solution (5 mL) and the aqueous layer was extracted with EtOAc (2×10 mL). Combined organics were washed with brine, dried over Na2SO4, filtered and evaporated to dryness. The residue was purified by silica gel flash chromatography eluting with a 0 to 5% MeOH-DCM gradient to give the title compound (0.015 g, 20%) as a yellow oil which was used with no further purification. MS: 321.3 and 323.2 (M+H+).

Provenance & Evidence