HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanesulfonamide → N-((5-Bromo-4-methylpyridin-3-yl)methyl)ethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanesulfonamide | HCID 73702 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-Bromo-4-methylpyridine-3-carbaldehyde | HCID 22238337 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-((5-Bromo-4-methylpyridin-3-yl)methyl)ethanesulfonamide | HCID 86679144 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-11, 5-bromo-4-methyl-pyridine-3-carbaldehyde has been reacted first with ethanesulfonamide, followed by reduction of the thus formed imine with NaBH4 in MeOH to give the title compound as an off-white solid. MS: 293.1 and 295.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-f63f27579531424d8241278eb80c00e8 |
| Source note | uspto-grants-2016_02 |