HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → N-((5-Bromopyridin-3-yl)methyl)-3-chloro-N-methylpicolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-((5-Bromopyridin-3-yl)methyl)-3-chloropicolinamide | HCID 86679147 | — |
| Product | N-((5-Bromopyridin-3-yl)methyl)-3-chloro-N-methylpicolinamide | HCID 86679148 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-41, N-((5-bromopyridin-3-yl)methyl)-3-chloropicolinamide (intermediate A-56) was reacted with MeI in presence of NaH (60% in mineral oil) to give the title compound as a dark brown oil. MS: 340.2 and 342.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-85cbf158a57d478791e753e0fa53063e |
| Source note | uspto-grants-2016_02 |