HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (R)-N-((5-Bromo-4-chloropyridin-3-yl)methyl)-2-methylpropane-2-sulfinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | tert-Butylsulfinamide, (R)-(+)- | HCID 10964479 | — |
| Reactant | 5-Bromo-4-chloropyridine-3-carbaldehyde | HCID 71742307 | — |
| Reactant | HCID 178455564 | HCID 178455564 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N-((5-Bromo-4-chloropyridin-3-yl)methyl)-2-methylpropane-2-sulfinamide | HCID 86679149 | — |
Reaction Steps
(R)-2-Methyl-propane-2-sulfinic acid 1-(5-bromo-4-chloro-pyridin-3-yl)-meth-(E)-ylideneamide, prepared from (R)-2-methylpropane-2-sulfinamide and 5-bromo-4-chloro-pyridine-3-carbaldehyde in analogy to procedure described for the preparation of intermediate A-35 [A], has been reduced with NaBH4 in MeOH in analogy to the procedure described for the preparation of intermediate A-35 [B] to give the title compound as a yellow oil. MS: 325.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-1bbcf602265c4e18bb6aaf76c543ad8c |
| Source note | uspto-grants-2016_02 |