Thionyl Chloride → HCID 86679152, compound

HRID 1774788Notes

Reaction equation

O[CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[CH:9]=[C:10]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]([CH3:24])[C:19](=[O:25])[CH2:18][CH2:17]3)[CH:11]=[N:12][CH:13]=1.S(Cl)([Cl:28])=O>>[Cl:28][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]1[CH:9]=[C:10]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]([CH3:24])[C:19](=[O:25])[CH2:18][CH2:17]3)[CH:11]=[N:12][CH:13]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 71533200HCID 71533200, compound

Product 1

HCID 86679152HCID 86679152, compound

Procedure

In analogy to the procedure described for the preparation of intermediate A-5 [B], 6-[5-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one (example 5) has been reacted with thionyl chloride to give the title compound as an orange oil. MS: 356.1 (M+H+).

Sources & evidence

ORD record: ord-12b473edb299418d86735e5c9cbc280f
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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