2,6-Dichloropyrazine → HCID 86679156, compound

HRID 1774793Notes

Reaction equation

HRID 1774793 reaction equation
[NH2:1][C@H:2]([CH:5]([CH3:7])[CH3:6])[CH2:3][OH:4].[Cl:8][C:9]1[CH:14]=[N:13][CH:12]=[C:11](Cl)[N:10]=1>>[Cl:8][C:9]1[N:10]=[C:11]([NH:1][C@H:2]([CH:5]([CH3:7])[CH3:6])[CH2:3][OH:4])[CH:12]=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 6950587D-Valinol

Product 1

HCID 86679156HCID 86679156, compound

Procedure

In analogy to the procedures described for the preparation of intermediate A-20 and A-3 [C]: i) (R)-2-amino-3-methyl-butan-1-ol has been reacted with 2,6-dichloropyrazine to give (R)-2-(6-chloro-pyrazin-2-ylamino)-3-methyl-butan-1-ol; ii) subsequent condensation with 1-methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one (intermediate A-1) gave the title compound as a light yellow solid. MS: 341.2 (M+H+).

Workup

  1. customIn analogy to the procedures described for the preparation of intermediate A-20 and A-3 [C]

Sources & evidence

ORD record
ord-3a19df59896e4e82b9cf6cf82f97a704
Source dataset
uspto-grants-2016_02
Patent number
US09260408B2

Reaction notes

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