HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 86679169, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one | HCID 72208233 | — |
| Reactant | HCID 86679168 | HCID 86679168 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Product | HCID 86679169 | HCID 86679169 | — |
Reaction Steps
In analogy to the procedure described for the preparation of example 59 [C], potassium 2-(5-bromopyridin-3-yl)-2-methylpropanoate (example 72 [B]) was reacted with 1-methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one (intermediate A-1) in presence of bis(triphenylphosphine)palladium(II)chloride and Na2CO3 (1M aq. solution) to give the title compound as a brown foam. MS: 325.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-032f3545ca2f48388fd6eccfe5b2d057 |
| Source note | uspto-grants-2016_02 |