HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Aminomethyl)-5-bromopyridine → 6-(5-Aminomethyl-pyridin-3-yl)-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Aminomethyl)-5-bromopyridine | HCID 22992264 | — |
| Reactant | HCID 86679131 | HCID 86679131 | — |
| Product | 6-(5-Aminomethyl-pyridin-3-yl)-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one | HCID 71533635 | — |
Reaction Steps
In analogy to the procedure described for the preparation of example 45, reaction of 3-aminomethyl-5-bromopyridine and 7-fluoro-1-methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one (intermediate A-22) gave the title compound as a light yellow solid. MS: 286.7 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-883f6ae7565d41bda0d3c7c66207f527 |
| Source note | uspto-grants-2016_02 |