HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Aminomethyl)-5-bromopyridine → 6-(5-Aminomethyl-pyridin-3-yl)-3,4-dihydro-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Aminomethyl)-5-bromopyridine | HCID 22992264 | — |
| Reactant | 3,4-Dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-2(1H)-one | HCID 59117187 | — |
| Product | 6-(5-Aminomethyl-pyridin-3-yl)-3,4-dihydro-1H-quinolin-2-one | HCID 86679176 | — |
Reaction Steps
In analogy to the procedure described for the preparation of example 45, reaction of 3-aminomethyl-5-bromopyridine and 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one (intermediate A-34) gave the title compound as a light yellow amorphous solid. MS: 254.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-fd0794a060c345c6b29b593fffbd99e1 |
| Source note | uspto-grants-2016_02 |