HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 3-Chloro-pyridine-2-carboxylic acid [5-(8-chloro-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-methyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 3-Chloro-pyridine-2-carboxylic acid methyl-[5-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amide | HCID 86679197 | — |
| Product | 3-Chloro-pyridine-2-carboxylic acid [5-(8-chloro-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-methyl-amide | HCID 86679198 | — |
Reaction Steps
In analogy to the procedure described for the preparation of example 203, 3-chloro-pyridine-2-carboxylic acid methyl-[5-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amide (example 215) was reacted with N-chloro-succinimide to give the title compound as a light brown solid. MS: 441.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-8fb95ea105d14fa79bd86b98c16f704b |
| Source note | uspto-grants-2016_02 |