Hydrochloric Acid → 6-(5-Aminomethyl-4-methyl-pyridin-3-yl)-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride

Participants

Reaction Steps

In analogy to the procedure described for the preparation of example 42, reaction of (R)-2-methyl-propane-2-sulfinic acid [4-methyl-5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amide (example 221) with hydrogen chloride (in dixoane) in methanol gave the title compound as a yellow solid. MS: 282.5 (M+H+).

Provenance & Evidence