3,5-Dimethylisoxazole-4-carboxylic acid → 3,5-Dimethyl-isoxazole-4-carboxylic acid [4-methyl-5-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-ylmethyl]-amide

Participants

Reaction Steps

In analogy to the procedure described for the preparation of example 219, 6-(5-aminomethyl-4-methyl-pyridin-3-yl)-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 222) has been coupled with 3,5-dimethyl-isoxazole-4-carboxylic acid to give the title compound as an off-white solid. MS: 405.5 (M+H+).

Provenance & Evidence