HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanesulfonyl chloride → Ethanesulfonic acid {2-[5-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-ethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanesulfonyl chloride | HCID 11667 | — |
| Reactant | 6-[5-(2-Amino-ethoxy)-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride | HCID 86679223 | — |
| Product | Ethanesulfonic acid {2-[5-(7-fluoro-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-pyridin-3-yloxy]-ethyl}-amide | HCID 86679225 | — |
Reaction Steps
In analogy to the procedure described for the preparation of example 38, 6-[5-(2-amino-ethoxy)-pyridin-3-yl]-7-fluoro-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 238) and ethanesulfonyl chloride gave the title compound as an orange amorphous solid. MS: 408.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09260408B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-523768e971634d8a9780ca47dd622ff2 |
| Source note | uspto-grants-2016_02 |