Methanesulfonyl chloride → HCID 178481477, compound

HRID 1774879Notes

Reaction equation

Cl.[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([O:9][C:10]2[CH:11]=[C:12]([C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][CH:25]=3)[N:22]([CH3:26])[C:21](=[O:27])[CH2:20][CH2:19]4)[CH:13]=[N:14][CH:15]=2)[CH2:5][CH2:4]1.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>>[CH3:26][N:22]1[C:23]2[C:18](=[CH:17][C:16]([C:12]3[CH:11]=[C:10]([O:9][C@H:6]4[CH2:5][CH2:4][C@H:3]([NH:2][S:29]([CH3:28])(=[O:31])=[O:30])[CH2:8][CH2:7]4)[CH:15]=[N:14][CH:13]=3)=[CH:25][CH:24]=2)[CH2:19][CH2:20][C:21]1=[O:27]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178481476HCID 178481476, compound

Product 1

HCID 178481477HCID 178481477, compound

Procedure

In analogy to the procedure described for the preparation of example 38, 6-[5-((trans)-4-amino-cyclohexyloxy)-pyridin-3-yl]-1-methyl-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 71) and methanesulfonyl chloride gave the title compound as a light yellow amorphous solid. MS: 430.4 (M+H+).

Sources & evidence

ORD record: ord-b573e2669ac440d68961194de8307ba9
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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