Acetyl chloride → HCID 86679233, compound

HRID 1774883Notes

Reaction equation

Cl.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[CH:14]=[N:15][CH:16]=[C:17]([O:19][C@H:20]4[CH2:24][CH2:23][NH:22][CH2:21]4)[CH:18]=3)=[CH:10][CH:11]=2)[CH2:6][CH2:5][C:4]1=[O:25].[C:26](Cl)(=[O:28])[CH3:27]>>[C:26]([N:22]1[CH2:23][CH2:24][C@H:20]([O:19][C:17]2[CH:18]=[C:13]([C:9]3[CH:8]=[C:7]4[C:12](=[CH:11][CH:10]=3)[N:3]([CH3:2])[C:4](=[O:25])[CH2:5][CH2:6]4)[CH:14]=[N:15][CH:16]=2)[CH2:21]1)(=[O:28])[CH3:27]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 86679170HCID 86679170, compound

Product 1

HCID 86679233HCID 86679233, compound

Procedure

In analogy to the procedure described in example 76, 1-methyl-6-[5-((S)-pyrrolidin-3-yloxy)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 60) has been reacted with acetyl chloride to give the title compound as a colorless solid. MS: 366.4 (M+H+).

Sources & evidence

ORD record: ord-fc6ad7f79b4847429e473058171cefb3
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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