Ethyl chloroformate → HCID 86679235, compound

HRID 1774885Notes

Reaction equation

Cl.[CH3:2][N:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[CH:14]=[N:15][CH:16]=[C:17]([O:19][C@H:20]4[CH2:24][CH2:23][NH:22][CH2:21]4)[CH:18]=3)=[CH:10][CH:11]=2)[CH2:6][CH2:5][C:4]1=[O:25].[CH2:26]([O:28][C:29](Cl)=[O:30])[CH3:27]>>[CH2:26]([O:28][C:29]([N:22]1[CH2:23][CH2:24][C@H:20]([O:19][C:17]2[CH:16]=[N:15][CH:14]=[C:13]([C:9]3[CH:8]=[C:7]4[C:12](=[CH:11][CH:10]=3)[N:3]([CH3:2])[C:4](=[O:25])[CH2:5][CH2:6]4)[CH:18]=2)[CH2:21]1)=[O:30])[CH3:27]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 86679170HCID 86679170, compound

Product 1

HCID 86679235HCID 86679235, compound

Procedure

In analogy to the procedure described in example 76, 1-methyl-6-[5-((S)-pyrrolidin-3-yloxy)-pyridin-3-yl]-3,4-dihydro-1H-quinolin-2-one hydrochloride (example 60) has been reacted with chloroformic acid ethyl ester to give the title compound as a light yellow amorphous solid. MS: 396.5 (M+H+).

Sources & evidence

ORD record: ord-9c7ce5a730a34bd5822bb14f2a9cf711
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09260408B2

Reaction notes

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